Effect of Adding Sildenafil to Clomiphene Citrate versus Clomiphene Citrate alone on Endometrium in Unexplained Infertility: Cross-Sectional, Non-Randomized Study

Effect of Adding Sildenafil to Clomiphene Citrate versus Clomiphene Citrate alone on Endometrium in Unexplained Infertility: Cross-Sectional, Non-Randomized Study

to a receptive endometrium suitable for implantation. One of the major drugs used for infertility treatment is clomiphene citrate (a non steroidal synthetic compound with both estrogenic and anti-estrogenic activity). Clomiphene citrate stimulates ovulation by competitively inhibiting the estrogen (E) binding to the hypothalamic estrogen receptors (ER), thereby releasing the hypothalamus from t...

Adding sildenafil vaginal gel to clomiphene citrate in infertile women with prior clomiphene citrate failure due to thin endometrium: a prospective self-controlled clinical trial

We aimed to investigate the effect of adding sildenafil vaginal gel to clomiphene citrate (CC) in infertile women with prior CC failure. METHODS This is a self- controlled clinical trial. Women with CC failure (in prior 5 cycles) and thin endometrium were recruited (N = 42). In their 6th (CC only) cycle, women continued on CC 100 mg/ day for 5 days, and had measurement of endometrial thicknes...

The Impact of Letrozole Versus Clomiphene Citrate on Uterine Blood Flow in Patients with Unexplained Infertility

OBJECTIVE To compare the effectiveness of letrozole and clomiphene citrate (CC) on uterine blood flow rate in patients with unexplained infertility. MATERIALS AND METHODS In this randomized clinical trial 90 women with unexplained infertility referred to a university clinic from January 2011- December 2013 were enrolled. Thirty patients were randomized for letrozole, 30 patients for CC and 3o...

Letrozole versus Clomiphene Citrate in Patients with Anovulatory Infertility

Objective: To compare the effectiveness of letrozole and clomiphene citrate (CC) in patients with anovulatory infertility. Design: Open, prospective, randomized, parallel group, multicentric, comparative trial. Setting: Outpatient clinics of infertility centers in India. Patient(s): Fifty-five patients with anovulatory infertility were recruited. Twenty-seven patients (59 cycles) were given let...

Does Adding Dexamethasone to Clomiphene Citrate Improve Ovulation in PCOS Patients? A Triple - Blind Randomized Clinical Trial Study